β-CGRP, human TFA
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 3907.38 |
| Molecular Formula | C164H268F3N51O50S3 |
| SMILES | - |
Summary
β-CGRP, human TFA (Human β-CGRP TFA) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC 50 s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells [1] .
IC50 & Target
IC50: 1 nM (CRLR/RAMP1, cell assay), 300 nM (CRLR/RAMP2, cell assay) [1]
In Vitro
β-CGRP, human is one of calcitonin peptides, acts via complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC 50 s of 1 nM in both SK-N-MC and Swiss 3T3 cells express CRLR and RAMP1, and 130 nM and 300 nM in NG108-15 and HEK293T cells expressing CRLR and RAMP2 [1] . CGRP is a potent vasodilator and also shows pro- and -anti-inflammatory activity [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 25 mg/mL ( 6.40 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.2559 mL | 1.2796 mL | 2.5593 mL |
| 5 mM | 0.0512 mL | 0.2559 mL | 0.5119 mL |
| 10 mM | --- | --- | --- |
-
1.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (12.80 mM); Clear solution; Need ultrasonic
References
