Autocamtide-2-related inhibitory peptide TFA
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 1611.76 |
| Molecular Formula | C66H126N22O21F3 |
| SMILES | - |
1 Publications Citing Use of MCE
Summary
Autocamtide-2-related inhibitory peptide (TFA) is a highly specific and potent inhibitor of CaMKII with an IC 50 of 40 nM.
IC50 & Target
IC50: 40 nM (CaMKII) [1] .
In Vitro
It is found that Autocamtide-2-related inhibitory peptide (TFA) is a potent inhibitor of CaM-kinase II with an IC 50 of 40 nM, which is active in the presence or absence of Ca 2+ /calmodulin. It is 50 and 500 times more potent than CaMK-(281-302Ala286) and KN-93, respectively, under the assay condition used [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 110 mg/mL ( 68.25 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.6204 mL | 3.1022 mL | 6.2044 mL |
| 5 mM | 0.1241 mL | 0.6204 mL | 1.2409 mL |
| 10 mM | 0.0620 mL | 0.3102 mL | 0.6204 mL |
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1.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (31.02 mM); Clear solution; Need ultrasonic
