[CAS NO. 91-33-8] Benzthiazide
PRODUCTS SPECIFICATIONS [91-33-8]
DESCRIPTION [91-33-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 431.94 |
| Molecular Formula | C15H14ClN3O4S3 |
| SMILES | O=S(C1=C(Cl)C=C(C2=C1)NC(CSCC3=CC=CC=C3)=NS2(=O)=O)(N)=O |
1 Publications Citing Use of MCE
Summary
Benzthiazide is a long-acting diuretic [1] and a hypertension agent. Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9) , with K i s of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively. Benzthiazide also suppresses proliferation of cancer cells [2] .
IC50 & Target
Ki: 8.0 nM (CA9), 8.8 nM (CA2), 10 nM (CA1) [2]
In Vitro
Benzthiazide (0.4, 2, 10 μM) suppresses proliferation of cancer cell under hypoxic conditions in a dose-dependent manner
.
Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with K
i
s of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Benzthiazide (1, 1.5 mg/100 g BW) causes a marked decrease in urinary calcium excretion and the dissociation of calcium and sodium excretion in hyperprolactinemic rats [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 115.76 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3151 mL | 11.5757 mL | 23.1514 mL |
| 5 mM | 0.4630 mL | 2.3151 mL | 4.6303 mL |
| 10 mM | 0.2315 mL | 1.1576 mL | 2.3151 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.82 mM); Clear solution
References
Synonyms
