[CAS NO. 456-12-2] Aegeline
PRODUCTS SPECIFICATIONS [456-12-2]
DESCRIPTION [456-12-2]
Overview
| MDL | MFCD00048045 |
|---|---|
| Molecular Weight | 297.35 |
| Molecular Formula | C18H19NO3 |
| SMILES | O=C(NCC(O)C1=CC=C(OC)C=C1)/C=C/C2=CC=CC=C2 |
Summary
Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax . Antioxidant activity [1] .
In Vitro
Aegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein or
Bax-expressing cells
[1]
.
Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 336.30 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3630 mL | 16.8152 mL | 33.6304 mL |
| 5 mM | 0.6726 mL | 3.3630 mL | 6.7261 mL |
| 10 mM | 0.3363 mL | 1.6815 mL | 3.3630 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (8.41 mM); Clear solution
References
- [1] Derf A, et al. a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast [published correction appears in Bioorg Med Chem Lett. 2019 Aug 15;29(16):2437-2438]. Bioorg Med Che
- [2] Nugroho AE, et al. Effects of aegeline, a main alkaloid of Aegle Marmelos Correa leaves, on the histamine release from mast cells. Pak J Pharm Sci. 2011;24(3):359‐367.
Synonyms
