[CAS NO. 38048-32-7] Nitrobenzylthioinosine

Name: Nitrobenzylthioinosine
Brand: Arctom Scientific
SKU: HY-W010936

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PRODUCTS SPECIFICATIONS [38048-32-7]

Distributor

Catalog

HY-W010936

Brand

MCE

CAS

38048-32-7

DESCRIPTION [38048-32-7]

Overview

MDL	MFCD00005745
Molecular Weight	419.41
Molecular Formula	C17H17N5O6S
SMILES	OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C(N=CN=C32)SCC4=CC=C([N+]([O-])=O)C=C4)O1)O)O

For research use only. We do not sell to patients.

Summary

Nitrobenzylthioinosine is an ENT1 transporter inhibitor that binds to ENT1 transporter with high affinity. Nitrobenzylthioinosine is a photoaffinity probe for adenosine uptake sites in brain. Nitrobenzylthioinosine can cross the blood-brain barrier ^[1] ^[2] ^[3] .

IC50 & Target

ENT1 transporter ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 119.22 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3843 mL	11.9215 mL	23.8430 mL
5 mM	0.4769 mL	2.3843 mL	4.7686 mL
10 mM	0.2384 mL	1.1922 mL	2.3843 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (4.96 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.96 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.96 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Inosine, 6-S-[(4-nitrophenyl)methyl]-6-thio-

6-S-[(4-Nitrophenyl)methyl]-6-thioinosine

6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine

S-(p-Nitrobenzyl)-6-mercapto-9-β-D-ribofuranosylpurine

S-(4-Nitrobenzyl)-6-thioinosine

NSC 296962

NBMPR

6-[(4-Nitrobenzyl)thio)inosine

2-(Hydroxymethyl)-5-[6-[(4-nitrophenyl)methylsulfanyl]purin-9-yl]oxolane-3,4-diol

2-(Hydroxymethyl)-5-[6-[(4-nitrophenyl)methylthio]purin-9-yl]oxolane-3,4-diol