[CAS NO. 3371-85-5] Voacamine
PRODUCTS SPECIFICATIONS [3371-85-5]
DESCRIPTION [3371-85-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 704.90 |
| Molecular Formula | C43H52N4O5 |
| SMILES | O=C(C1(C(C(C2)CC)N3CC2C1)C4=C(CC3)C(C=C(OC)C([C@H](CC(/C(CN5C)=C/C)C(C(OC)=O)[C@H]5C6)C7=C6C(C=CC=C8)=C8N7)=C9)=C9N4)OC |
Summary
Voacamine, an indole alkaloid, exhibits potent cannabinoid CB1 receptor antagonistic activity [1] . Voacamine also inhibits P-glycoprotein ( P-gp ) action in multidrug-resistant tumor cells [1] .
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 141.86 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.4186 mL | 7.0932 mL | 14.1864 mL |
| 5 mM | 0.2837 mL | 1.4186 mL | 2.8373 mL |
| 10 mM | 0.1419 mL | 0.7093 mL | 1.4186 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: 2.5 mg/mL (3.55 mM); Suspended solution; Need ultrasonic
References
- [1] Kitajima M, et al. Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1962-4.
- [2] Meschini S, et al. Voacamine, an alkaloid extracted from , inhibits P-glycoprotein action in multidrug-resistant tumor cells. Int J Oncol. 2005 Dec;27(6):1597-603.
Synonyms
