[CAS NO. 2238821-31-1] EZH2-IN-2

Name: EZH2-IN-2
Brand: Arctom Scientific
SKU: HY-A0298

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PRODUCTS SPECIFICATIONS [2238821-31-1]

Distributor

Catalog

HY-A0298

Brand

MCE

CAS

2238821-31-1

DESCRIPTION [2238821-31-1]

Overview

MDL	-
Molecular Weight	610.79
Molecular Formula	C36H46N6O3
SMILES	O=C(NCC1=C(C)C=C(C)NC1=O)C2=CC(C3=CC=C(N4CCN(CC5CC5)CC4)N=C3C)=CC(N(C(C6CC6)=O)CC)=C2C

For research use only. We do not sell to patients.

Summary

EZH2-IN-2 is a EZH2 inhibitor extracted from patent WO2018133795A1, Compound Example 69, with an IC ₅₀ of 64 nM. EZH2-IN-2 can be used for the research of cancer or precancerous condition related to EZH2 activity ^[1] .

IC50 & Target

EZH2

64 nM (IC ₅₀ )

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL ( 16.37 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6372 mL	8.1861 mL	16.3722 mL
5 mM	0.3274 mL	1.6372 mL	3.2744 mL
10 mM	0.1637 mL	0.8186 mL	1.6372 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1 mg/mL (1.64 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1 mg/mL (1.64 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1 mg/mL (1.64 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] LIU, Qing Song, et al. Ezh2 inhibitor and use thereof. WO2018133795A1.