[CAS NO. 22144-77-0] Cytochalasin D

Name: Cytochalasin D
Brand: Arctom Scientific
SKU: HY-N6682

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PRODUCTS SPECIFICATIONS [22144-77-0]

Distributor

Catalog

HY-N6682

Brand

MCE

CAS

22144-77-0

DESCRIPTION [22144-77-0]

Overview

MDL	-
Molecular Weight	507.62
Molecular Formula	C30H37NO6
SMILES	C=C1[C@@H](O)[C@@]2([H])[C@@]3([C@H](OC(C)=O)/C=C/[C@](O)(C)C([C@@H](C)C/C=C/2)=O)[C@@]([C@H](CC4=CC=CC=C4)NC3=O)([H])[C@@H]1C

For research use only. We do not sell to patients.

18 Publications Citing Use of MCE

Summary

Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap ^[1] ^[2] ^[3] ^[4] .

In Vitro

Cytochalasin D (3 and 10 μM; 30 min) causes retraction and arborization of COS-7 cells and conversion of F-actin from long fibers to punctate structures ^[1] .
Cytochalasin D (0.3, 1, 3 and 10 μM; 30 min) concentration-dependently decreases the rate of actin depolymerization in COS-7 cells ^[1] .
Cytochalasin D (1 μM; NIH3T3 cells) disrupts stress fibers, induces phosphorylation of Yap, while cells maintains original area and lost nuclear Yap localization ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	COS-7 cells ^[1]
Concentration:	3 and 10 μM
Incubation Time:	30 min
Result:	Caused retraction and arborization of COS-7 cells and conversion of F-actin from long fibers to punctate structures.

Western Blot Analysis

Cell Line:	COS-7 cells expressing YFP-actin ^[1]
Concentration:	0.3, 1, 3 and 10 μM
Incubation Time:	30 min
Result:	Concentration-dependently decreased the rate of actin depolymerization in COS-7 cells.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT03677492	Ibn Sina Hospital	Infertility	September 25, 2018	Not Applicable

Appearance

Solid

Source

molds

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 49.25 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9700 mL	9.8499 mL	19.6998 mL
5 mM	0.3940 mL	1.9700 mL	3.9400 mL
10 mM	0.1970 mL	0.9850 mL	1.9700 mL

* Please refer to the solubility information to select the appropriate solvent.

References

Synonyms

1H-Cycloundec[d]isoindole-1,11(2H)-dione, 15-(acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-

[11]Cytochalasa-6(12),13,19-triene-1,17-dione, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E,21R)-

(3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-15-(Acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-1H-cycloundec[d]isoindole-1,11(2H)-dione

Cytochalasin D

Zygosporin A

1H-Cycloundec[d]isoindole-1,11(2H)-dione, 15-(acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, [3S-(3R*,3aS*,4R*,6R*,6aS*,7E,10R*,12S*,13E,15S*,15aS*)]-

(-)-Cytochalasin D

NSC 209835