[CAS NO. 2127-03-9] 2,2′-Dipyridyl disulfide

Name: 2,2′-Dipyridyl disulfide
Brand: Arctom Scientific
SKU: HY-Y1666

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PRODUCTS SPECIFICATIONS [2127-03-9]

Distributor

Catalog

HY-Y1666

Brand

MCE

CAS

2127-03-9

DESCRIPTION [2127-03-9]

Overview

MDL	MFCD00006287
Molecular Weight	220.31
Molecular Formula	C10H8N2S2
SMILES	C1(SSC2=NC=CC=C2)=NC=CC=C1

For research use only. We do not sell to patients.

Summary

2,2′-Dipyridyl disulfide is a useful reagent for the determination of sulfhydryl groups. 2,2′-Dipyridyl disulfide is a common reagent in peptide chemistry, often used in oxidation–reduction condensations to form peptide bonds or in coupling reactions to form disulfide-linked heterodimers ^[1] .

In Vitro

Formation of intramolecular S–S bonds can be dramatically accelerated by addition of a 2,2′-Dipyridyl disulfide (2-PDS) solution to an air-oxidized mixture of cysteine-containing peptides ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 453.91 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5391 mL	22.6953 mL	45.3906 mL
5 mM	0.9078 mL	4.5391 mL	9.0781 mL
10 mM	0.4539 mL	2.2695 mL	4.5391 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (11.35 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (11.35 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (11.35 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] K Maruyama, et al. 2,2'-Bispyridyl disulfide rapidly induces intramolecular disulfide bonds in peptides. Peptides. 1999;20(7):881-4.

Synonyms

Pyridine, 2,2′-dithiobis-

Pyridine, 2,2′-dithiodi-

2,2′-Dithiobis[pyridine]

2,2′-Dithiodipyridine

2,2′-Dipyridyl disulfide

Bis(2-pyridyl) disulfide

Di-2-pyridyl disulfide

Bis(2-pyridinyl) disulfide

2-Pyridyl disulfide

Aldrithiol 2

2,2′-Dipyridinyl disulfide

NSC 677438

2-Aldrithiol

NSC 94055

Bis(pyridin-2-yl) disulfide

1,2-Bis(2-pyridinyl) disulfide

2,2′-Bipyridyl disulfide

2′-Aldrithiol

Di-2-pyridinyl disulfide

2,2′-Disulfanediyldipyridine

1,2-Di(pyridin-2-yl)disulfane

2,2-Dithiobispyridine

2-(Pyridin-2-yldisulfanyl)pyridine