[CAS NO. 2125450-76-0] Eclitasertib

Name: Eclitasertib
Brand: Arctom Scientific
SKU: HY-114371

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PRODUCTS SPECIFICATIONS [2125450-76-0]

Distributor

Catalog

HY-114371

Brand

MCE

CAS

2125450-76-0

DESCRIPTION [2125450-76-0]

Overview

MDL	-
Molecular Weight	378.38
Molecular Formula	C19H18N6O3
SMILES	O=C(C1=NN=C(CC2=CC=CC=C2)N1)N[C@@H]3C(N(C)C4=NC=CC=C4OC3)=O

For research use only. We do not sell to patients.

Summary

Eclitasertib (DNL-758) is a potent receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC ₅₀ of <1 µΜ (From patent WO2017136727A2, example 42) ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 330.36 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6428 mL	13.2142 mL	26.4285 mL
5 mM	0.5286 mL	2.6428 mL	5.2857 mL
10 mM	0.2643 mL	1.3214 mL	2.6428 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.50 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.50 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.50 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Anthony A. ESTRADA, et al. Compounds, compositions and methods. WO2017136727A2.