[CAS NO. 161058-83-9] NU2058
PRODUCTS SPECIFICATIONS [161058-83-9]
DESCRIPTION [161058-83-9]
Overview
| MDL | MFCD05664734 |
|---|---|
| Molecular Weight | 247.30 |
| Molecular Formula | C12H17N5O |
| SMILES | NC1=NC(OCC2CCCCC2)=C3NC=NC3=N1 |
Summary
IC50 & Target
|
CDK1 26 μM (IC 50 ) |
CDK2 17 μM (IC 50 ) |
CDK2 12 μM (Ki) |
In Vitro
NU2058 (O6-(Cyclohexylmethyl)guanine) is a competitive inhibitor of CDK2 with respect to ATP (Ki value CDK2, 12 μM) that binds in the ATP binding pocket in a different orientation from other purine-based inhibitors, including olomoucine and roscovotine. NU2058 is the lead compound in a structure-based drug discovery program to develop more potent and selective CDK inhibitors.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 32 mg/mL ( 129.40 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.0437 mL | 20.2184 mL | 40.4367 mL |
| 5 mM | 0.8087 mL | 4.0437 mL | 8.0873 mL |
| 10 mM | 0.4044 mL | 2.0218 mL | 4.0437 mL |
