[CAS NO. 1504-74-1] 2-Methoxycinnamaldehyde
PRODUCTS SPECIFICATIONS [1504-74-1]
DESCRIPTION [1504-74-1]
Overview
| MDL | MFCD00007001 |
|---|---|
| Molecular Weight | 162.19 |
| Molecular Formula | C10H10O2 |
| SMILES | O=C/C=C/C1=CC=CC=C1OC |
Summary
2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia , with antitumor activity [1] [2] [3] . 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase-3 and caspase-9 [2] . 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration [3] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL ( 616.56 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 6.1656 mL | 30.8280 mL | 61.6561 mL |
| 5 mM | 1.2331 mL | 6.1656 mL | 12.3312 mL |
| 10 mM | 0.6166 mL | 3.0828 mL | 6.1656 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (15.41 mM); Clear solution
References
- [1] Wong HY, et al. Cinnamomum verum Component 2-Methoxycinnamaldehyde: A Novel Anticancer Agent with Both Anti-Topoisomerase I and II Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo. Phytother Res. 2016 Feb;30(2):331-40.
- [2] Liu YH, et al. Cinnamomum verum ingredient 2-methoxycinnamaldehyde: a new antiproliferative drug targeting topoisomerase I and II in human lung squamous cell carcinoma NCI-H520 cells. Eur J Cancer Prev. 2017 Jul;26(4):314-323.
- [3] Jin YH, et al. 2-Methoxycinnamaldehyde inhibits the TNF-α-induced proliferation and migration of human aortic smooth muscle cells. Int J Mol Med. 2017 Jan;39(1):191-198.
Synonyms
