[CAS NO. 131-57-7] Oxybenzone
PRODUCTS SPECIFICATIONS [131-57-7]
DESCRIPTION [131-57-7]
Overview
| MDL | MFCD00008387 |
|---|---|
| Molecular Weight | 228.24 |
| Molecular Formula | C14H12O3 |
| SMILES | O=C(C1=CC=C(OC)C=C1O)C2=CC=CC=C2 |
1 Publications Citing Use of MCE
Summary
Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy , alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells [1] [2] [3] .
In Vitro
Oxybenzone (Benzophenone 3) (25 μM; 24 hours) decreases the relative RXRβ and RXRγ protein levels by 61 and 56%, respectively and increases the relative RXRα protein level by 49%
[3]
.
Oxybenzone (25-100 μM; 24 hours) induces an increase in caspase-3 levels in primary cultures of mouse neocortical cells at 7 DIV. Oxybenzone-induced apoptosis involves the activation of RXRα signaling and the impairment of RXRβ/RXRγ signaling. Oxybenzone (25 μM; 24 hours) inhibits global DNA methylation as well as reduced HDAC and HAT activities in mouse embryonic neuronal cells
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [3]
| Cell Line: | Mouse neocortical cells at 7 DIV |
| Concentration: | 25 μM |
| Incubation Time: | 24 hours |
| Result: | Exposure to Oxybenzone (25 μM) for 24 h decreased the relative RXRβ and RXRγ protein levels by 61 and 56%, respectively. Treatment with Oxybenzone (25 μM) increased the relative RXRα protein level by 49%. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 438.14 mM ; Need ultrasonic)
H 2 O : 1 mg/mL ( 4.38 mM ; ultrasonic and warming and heat to 80°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.3814 mL | 21.9068 mL | 43.8135 mL |
| 5 mM | 0.8763 mL | 4.3814 mL | 8.7627 mL |
| 10 mM | 0.4381 mL | 2.1907 mL | 4.3814 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 5 mg/mL (21.91 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (10.95 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (10.95 mM); Clear solution
References
- [1] Wnuk A, et al. Prenatal exposure to benzophenone-3 (BP-3) induces apoptosis, disrupts estrogen receptor expression and alters the epigenetic status of mouse neurons. J Steroid Biochem Mol Biol. 2018;182:106-118.
- [2] DiNardo JC, et al. Can oxybenzone cause Hirschsprung's disease?. Reprod Toxicol. 2019;86:98-100.
- [3] Wnuk A, et al. Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells. Mol Neurobiol. 2018;55(6):5059-5074.
Synonyms
