[CAS NO. 1198398-71-8] Coptisine Sulfate

Name: Coptisine Sulfate
Brand: Arctom Scientific
SKU: HY-N0430A

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PRODUCTS SPECIFICATIONS [1198398-71-8]

Distributor

Catalog

HY-N0430A

Brand

MCE

CAS

1198398-71-8

DESCRIPTION [1198398-71-8]

Overview

MDL	MFCD20526610
Molecular Weight	417.39
Molecular Formula	C19H15NO8S
SMILES	O=S(O)([O-])=O.C1(C(CC[N+]2=C1C=C(C=C3)C(C4=C3OCO4)=C2)=C5)=CC6=C5OCO6

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

Coptisine Sulfate is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a K _i value of 5.8 μM and an IC ₅₀ value of 6.3 μM ^[1] .

IC50 & Target

IC50: 6.3 μM (IDO) ^[1]
Ki: 5.8 μM (IDO) ^[1]

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 1 mg/mL ( 2.40 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3958 mL	11.9792 mL	23.9584 mL
5 mM	---	---	---
10 mM	---	---	---

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302.