[CAS NO. 1023814-45-0] OUL245
PRODUCTS SPECIFICATIONS [1023814-45-0]
DESCRIPTION [1023814-45-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 191.21 |
| Molecular Formula | C8H5N3OS |
| SMILES | C1=CC2=C(C=C1O)SC3=NN=CN23 |
Summary
IC50 & Target
|
PARP2 44 nM (IC 50 ) |
PARP-1 570 nM (IC 50 ) |
PARP3 8.8 μM (IC 50 ) |
PARP4 6.0 μM (IC 50 ) |
TNKS1 1.6 μM (IC 50 ) |
TNKS2 370 μM (IC 50 ) |
PARP10 2.9 μM (IC 50 ) |
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PARP14 6.7 μM (IC 50 ) |
PARP15 2.0 μM (IC 50 ) |
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In Vitro
OUL245 (1 μM; 10-12 d) unlike other derivatives, does not save cells overexpressing PARP10 from ADP ribosylation-dependent cell death
[1]
.
Pharmacokinetic Analysis
[1]
| water solubility μg/mL | GI P app ×10 -6 cm/s (RM %) | BBB P app ×10 -6 cm/s (RM %) | metabolic stablity % | stab in human plasma | stab. in MeOH | stab in PBS pH 7.4 |
| 24.91 | 0.019 | 0.164 | 95.05 | >24 | >24 | >24 |
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
